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KMID : 0364820180540010038
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Korean Journal of Microbiology
2018 Volume.54 No. 1 p.38 ~ p.45
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Cnestis palala (Lour.) Merr. extract suppresses Propionibacterium acnes-induced inflammation
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Shin Jin-Hak
Lee Eun-Hye
Kim Seon-Sook
Kongamany Sydara
Seo Su-Ryeon
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Abstract
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Acne is an inflammatory skin disease that occurs in puberty and young people. Propionibacterium acnes (P. acnes) is known to be a major cause of inflammation in acne. P. acnes proliferates within hair follicles blocked by overproduced sebum in the skin, and thereby activates monocytic cells to promote the secretion of pro-inflammatory cytokines. In this study, we investigated the possibility of Cnestis palala (Lour.) Merr. extract to diminish P. acnes-mediated inflammatory responses. We found that C. palala extract significantly attenuated P. acnes-induced pro-inflammatory cytokine expressions, such as IL-1β, IL-6, TNF-α, iNOS, and COX-2 in mouse macrophage RAW264.7 cells. Moreover, we observed that C. palala extract inhibited NF-κB transcriptional activation, which is the major transcription factor of inflammatory cytokine expression. Therefore, it is expected that C. palala extract has a potential as a therapeutic agent or supplement for the treatment P. acnesinduced inflammatory responses.
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KEYWORD
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Propionibacterium acnes, Cnestis palala (Lour.) Merr., inflammation, pro-inflammatory cytokine
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